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Best NFL Week 2 Underdogs Bets

Week 2 of the NFL schedule is underway and TheSportsGeek has our best NFL Week 2 underdogs. We’re going over the slate and looking for potential NFL upsets this week. The second week of the season opened last night in Kansas City at Arrowhead.

There are sure to be NFL Week 2 upsets. Bet the best NFL Week 2 underdogs at the top online NFL betting sites in 2022.

The Chiefs got Week 2 started with a 27-24 win over the Los Angeles Chargers. While the favorite won, the underdog covered the 4-point spread. The Chargers don’t get the win on the moneyline in an upset, but cover the spreads as an underdog at Arrowhead Stadium.

Justin Herbert's Pick-6 was the only one this century to occur in the red zone in the 4th quarter of a tie game. pic.twitter.com/SvOZCGKNnW

— ESPN Stats & Info (@ESPNStatsInfo) September 16, 2022


Herbert and tight end Gerald Everett were not on the same page on the goal line. Everett was sucking wind and wanted off the field following back-to-back receptions, so that may have had something to do with, but Herbert’s pass was ill-advised towards the inside of his target.

The Chargers had a late score to get within 3 points to cover the 4 points, but they fall to 1-1 while the Chiefs are perfect at 2-0 to open the 2022 campaign. There weren’t any big underdogs last week, but we did have some upsets.

The Steelers, Bears, and Seahawks were the most notable upsets in Week 1.

Pittsburgh beating the defending AFC Champions wasn’t that big of a surprise at TheSportsGeek. We had the Steelers on our list of NFL upsets in Week 1. The Bengals looked hungover, while the Steelers went into Cincinnati for a 23-20 win in overtime as a 6.5-point underdog.

The marquee NFL underdog to win straight up last week was the Seahawks in Russell Wilson’s return to Seattle. Geno Smith and the Seahawks got it done for a rude welcome-back gift to Wilson in a 17-16 final as 6 to 7-point underdogs.

Let’s get into our best NFL Week 2 underdogs and picks for this weekend. We’re looking for the most likely NFL Week 2 upsets. Head below for our top potential NFL upsets this week at TheSportsGeek.

NFL Week 2 Underdogs


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Tampa Bay Buccaneers vs. New Orleans Saints Predictions:

Buccaneers vs Saints Odds Courtesy of Bovada:


Tampa Bay Buccaneers
-2.5 (-115)
Over 44.5 (-105)

New Orleans Saints
+2.5 (-105)
Under 44.5 (-115)

The Tampa Bay Buccaneers opened their season at AT&T Stadium on Sunday Night Football against the Dallas Cowboys. The defense was flying around the ball in a 19-3 win in Texas.


The talented Buccaneers’ defense had a free run at a bad offense with Cooper Rush under center in the 4th quarter. Prescott passed for 134 yards with an interception before leaving the game.

The Buccaneers didn’t have to do anything exotic offensively. Dallas wasn’t moving the ball, so the Buccaneers were able to go conservative. Tom Brady passed for 212 yards with 1 touchdown and 1 interception.

Chris Godwin started last week after his status was up in the air, but he will be absent in Week 2 vs the New Orleans Saints.

Godwin will be absent and the injury report is filled with receivers. There are five Bucs’ receivers on the injury report, with Mike Evans and Julio Jones battling ailments at the moment.

Russell Gage, Breshard Perriman, Jones, Evans, and Godwin did not practice this week. Scotty Miller may be valuable for Brady at New Orleans.

I’m not convinced that the Buccaneers can just sit back offensively in this one. They are on back-to-back road games, which generally doesn’t bode well for the visiting team.

Brady and the Bucs have to make plays on offense in this one.

The Saints survived in their season opener, with a 27-26 win on the road at Atlanta against the Falcons. Jameis Winston made his return to the field after missing most of last year. Winston played well with 269 yards and 2 touchdowns.

Backup quarterback Taysom Hill had a big role in the offense, as he rushed for 81 yards and a touchdown on 4 carries. The defensive front of the Buccaneers should do a better job, but I have some faith in Winston through the air.

This should be a divisional showdown that goes down to the final minutes. Tampa is good, but the Saints haven’t been a good matchup for them. They’re 1-7 against the spread and 2-5 ATS at New Orleans in their last seven attempts. I’m on the home underdog at home in a potential upset.

Buccaneers vs. Saints Prediction


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Atlanta Falcons vs. Los Angeles Rams Predictions:

Falcons vs Rams Odds Courtesy of Bovada:


Atlanta Falcons
+10 (-110)
Over 46.5 (-110)

LA Rams
-10 (-110)
Under 46.5 (-110)

The Los Angeles Rams enter Week 2 of the NFL schedule looking to clean things up on both sides of the ball. In their first game since winning the Super Bowl, the favorites to win the Super Bowl this year, went into SoFi Stadium to deliver a big uppercut.


The Bills punched the Rams in the mouth and beat them up in all aspects of the game. They left Los Angeles with a 31-10 win behind a strong offense and stifling defense.

Matthew Stafford passed for 240 yards with 1 touchdown and 3 interceptions. Stafford was dealing with a bad elbow last week and that will continue to be the case until further notice.

He didn’t look in sync with his receivers and the whole game plan didn’t work out well.

Cooper Kupp continued to be a reception and yardage machine, but no one else decided to show up. Expect better from the Rams this week. However, the absence of Von Miller and some other defensive talent was noticeable.

Along with Miller, the Rams lost cornerback Darious Williams, nose tackle, Sebastian Joseph-Day, and an outside linebacker, Ogbonnia Okoronkwo.

The defense has to take a step back for the Rams. Marcus Mariota is unlikely to go off on the Rams, but he isn’t going to be shoutout by a Rams’ defense that regressed in the offseason.

Atlanta was unable to get the win, but fought hard in a 27-26 loss to a quality Saints squad in Week 1. Mariota had 215 yards passing, with 72 yards and a touchdown on the ground.

Kyle Pitts was unable to get involved, but he should have better success on the west coast vs the Rams.

The Rams are being overvalued again in Week 2. The public will side with the Rams heavily in this one, as there will be a strong inclination that they’re guaranteed to bounce back big. I’m not interested in the Rams as double-digit favorites, though. That’s an overinflated line.

Falcons vs. Rams Prediction


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Seattle Seahawks vs. San Francisco 49ers Predictions:

Seahawks vs 49ers Odds Courtesy of Bovada:


Seattle Seahawks
+9 (-115)
Over 40 (-110)

San Francisco 49ers
-9 (-105)
Under 40 (-110)

The Seattle Seahawks are amongst our NFL Week 2 underdogs this week. They are playing for back-to-back upsets after knocking off the Denver Broncos at home on Monday Night Football.

Geno Smith and the Seahawks spoiled the return to Seattle for Russell Wilson. It was the defense that really showed up to deliver a standout performance, though.

Wilson and the Broncos were unable to punch the ball into the end zone on Monday night. He passed for 340 yards, with Jerry Jeudy coming on nicely with 102 yards and a touchdown. However, the offense scored just 16 points on the Seahawks.

It was a big confidence booster for Smith, as he’s out to prove that he isn’t a temporary solution at quarterback this year. Smith passed for 195 yards and 2 touchdowns on 23 of 28 passing.

The offensive line outplayed expectations, as an inexperienced unit gave Smith all of the protection that he needed.

When he has protection, Smith can be a decent quarterback. He’s just not going to the Pro Bowl or going to be on the highlight reel too often. That said, the offense isn’t that empty, with Tyler Lockett, DK Metcalf, and Noah Fant all there in the passing game.

The beginning of the Trey Lance era didn’t go well, as he struggled with 164 yards and an interception on 13 of 28 passing. He gained 54 rushing yards on 13 attempts, but Lance must be better with the ball in the pocket.

The Bears upset the 49ers in a 19-10 final at Soldier Field.

Lance may develop into a reliable starter and franchise quarterback, but he’s not there, at least not yet. He looked like an inexperienced rookie last week against the Bears.

This should be easier versus the Seahawks at home, but I’m not willing to lay 9 points. The 49ers to win by double digits is a bet with no value. The Seahawks belong on your NFL Week 2 underdogs bets shortlist for Sunday.

Seahawks vs. 49ers Prediction


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Author: Russell Perry